LSD and Lysergamides: A brief introduction

LSD is one of the most popular psychedelics on the planet. First synthesized in 1938 by Swiss chemist Albert Hofmann, LSD has since had a profound impact on the world at large. Most people are familiar with LSD, but not everyone knows that there are a huge number of similar compounds called lysergamides.

This article will explore what LSD is, how it is made, and what other lysergamides are.

What is the History of LSD

As far as psychedelics go, LSD has some of the most interesting history. Since its development in 1938, LSD has singlehanded influenced and changed the direction of society. 

Albert Hofmann, the father of LSD, was originally studying the ergot fungus. His intentions were to identify some of the active constituents in the plant so that they could be used for pharmaceutical research. 

His original goal was to find a respiratory stimulant that could be useful for helping to fight pulmonary conditions. His first experience learning about the psychedelic effects of LSD was a mistake. When handling the compound, he accidentally absorbed some through his skin.

It wasn’t until 1943 that Hoffman intentionally consumed his research chemical. The day that he did this, April 19th, is commemorated across the world by psychedelic enthusiasts and is referred to as Bicycle day.

After the initial effects of LSD startled Hoffman, he asked his lab assistant to escort him home. They did so by bicycle. During his bicycle ride, Hoffman was struck by paranoia and fears, such that he asked his nextdoor neighbour — a doctor — to give him a routine checkup. Once the doctor deemed him healthy, he relaxed into the experience.

LSD continued to have a profound influence in the counterculture movement, especially during the hippie wave of the 1960s. Following this period, LSD was made illegal, although its influence can still be felt in certain parts of the world.

LSD Effects

Hoffman himself described his accidental LSD experience as such, and to-date, it remains one of the simplest and most complete descriptions of LSD.

  • “At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors.”

Hofmann noted that his experience dwindled after about two hours. However, modern research acknowledges that LSD tends to last much longer than that. In fact, its duration of action is often attested to be closer to 16 hours.

Researchers have discovered that microdosing LSD can counteract this long duration, and it’s suspected that this is what happened to Hoffman. By accidentally absorbing a small amount of the compound, he was able to experience some of its psychedelic effects without intentionally consuming it.

About Lysergamides

Lysergamides operate in a very similar way as LSD. They generally affect the serotonin system, where they influence the 5-HT-2A receptor as an agonist. While they do influence a number of other receptors, this is their primary source of action.

Lysergamides are very popular substances throughout research labs around the world. Because of their pharmaceutical potential, many researchers are focusing on the potential of lysergamides for medicinal purposes. 

LSD itself is the most common lysergamide, but there are a number of other compounds with similar effects. The further study of these compounds is leading to changes in the medical and psychiatric industry.

Legal Lysergamides

There are a number of lysergamides that are legal and can be obtained through the internet or by direct contact with pharmacies.

  • 1B-LSD, or 1-butanol-d-lysergic acid diethylamide, has been researched for some time.
  • 1cP-LSD (N1-(cyclopropylmethanol)-lysergic acid diethylamide) is another popular lysergamide that researchers are beginning to learn more about.
  • 1P-LSD, or 1-propionyl-lysergic acid diethylamide, is a functional analog of LSD and a homolog of ALD-52.

There are many other legal lysergamides that can be obtained for research purposes. Due to new scientific research protocol and technology that allows researchers to test whether or not a molecule can fit into the serotonin receptor prior to actually synthesizing it, a large new number of lysergamides and tryptamine-based psychedelics are in development.

Buy LSD and Lysergamides Online

If you are interested in learning how to buy lysergamides online, it’s not difficult. Researchers and chemists will be pleased to know that most lysergamides are legal throughout the world. Of course, this is not the case everywhere — you will have to check with your country’s local laws prior to purchasing anything.

Generally, you will have to be at least 18 years old to purchase lysergamides online.

LSD itself has been a schedule 1 drug in the United States, and classified as illegal nearly everywhere else, for decades. While it is possible to buy LSD online, you will not be able to do so within the bounds of the law.


LSD and lysergamides are among the most interesting chemicals on the planet. They have been studied for many years for their ability to produce marked changes in human consciousness due to their influence in the brain, especially on the 5-HT-2A serotonin receptor.

If you are interested to buy lysergamides online for research purposes, then you should make sure that your country of residence allows these chemicals to be imported.


Microdosing is a term used to describe the subtle use of a substance. LSD is incredibly potent on its own, so microdosing it requires people to identify extremely small amounts of the compound (several micrograms.)

Lysergamides are amides of lysergic acid. These molecules have both a phenethylamine and a tryptamine molecular group, as well as a carboxamide group attached to carbon number eight. These substances are generally psychedelic in nature.

LSD is a molecule strikingly similar to serotonin, one of the chief neurotransmitters in the human brain. LSD fits snugly in the serotonin receptor and creates a number of perceptual changes. Its similarity to serotonin is what allows it to be so potent.


Leave a Comment

Your email address will not be published. Required fields are marked *

Sign up to receive 10% OFF and the latest news